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The activity of canrenone is reported to be 10 - 33% that of Spironolactone. ... Indomethacin and mefenamic acid have been shown to inhibit the excretion of canrenone. ...

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This is because these agents inhibit intraocular carbonic anhydrase and thus the ... Spironolactone is metabolized to canrenone which is the active drug molecule. ...

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